Helping you understand MASLD/MASH, your risk, and your options.
Metabolic health keeps your body running in balance. As your largest internal organ, the liver manages over 500 key metabolic processes.
Keeping your liver healthy is essential to preventing conditions like MASLD (where fat builds up due to metabolic imbalances) and MASH, a more advanced stage where fat causes inflammation and tissue damage.
Metabolic dysfunction–associated steatotic liver disease: extra fat builds up in the liver of someone who also has a metabolic risk factor such as excess weight, type 2 diabetes, high blood pressure or high cholesterol.
Metabolic dysfunction–associated steatohepatitis: the more serious form, where that fat is joined by inflammation and liver-cell injury that can lead to scarring (fibrosis) and, over time, cirrhosis.
Metabolic dysfunction–associated steatotic liver disease: extra fat builds up in the liver of someone who also has a metabolic risk factor such as excess weight, type 2 diabetes, high blood pressure or high cholesterol.
Metabolic dysfunction–associated steatohepatitis: the more serious form, where that fat is joined by inflammation and liver-cell injury that can lead to scarring (fibrosis) and, over time, cirrhosis.
MASLD is closely tied to metabolic health. It can affect people of any age, including children but the risk is far higher with certain conditions.
Obesity
High blood pressure
Type 2 diabetes or prediabetes
High cholesterol or triglycerides
Insulin resistance
Obstructive sleep apnea
Also linked: PCOS, a family history of liver disease, and higher alcohol intake (a related condition called MetALD).
MASLD affects roughly a quarter of adults worldwide and rates are rising alongside obesity and type 2 diabetes.
~ 1 in 3
U.S. adults are estimated to have MASLD
20M+
Americans are estimated to be living with MASH
3 in 5
with MASLD have normal liver enzymes so routine tests can miss it
122M
U.S. adults projected to have MASLD by 2050
MASH Prevalence: 5.3%
Estimated MASH prevalence by region; a global health challenge.
2023
Liver experts worldwide renamed these conditions: NAFLD → MASLD and NASH → MASH to better reflect their metabolic cause and remove stigma. You may still hear the older names from your care team.
Left unaddressed, MASLD can progress from simple fat, to inflammation, to permanent scarring.
Healthy
Inflamed
Fibrotic
Treatment is tailored to each person and usually combines healthy-lifestyle changes with care for related conditions and, when needed, medication.
The foundation of effective liver care relies on three key habits: eating well, staying active, and losing weight gradually.
Controlling diabetes, cholesterol and blood pressure eases the strain on your liver.
FDA-approved MASH treatments now include resmetirom (Rezdiffra™) and semaglutide (Wegovy®) alongside diet and exercise.
Because MASH can change over time, doctors track the liver and adjust care and may refer you to a liver specialist.
The foundation of effective liver care relies on three key habits: eating well, staying active, and losing weight gradually.
Controlling diabetes, cholesterol and blood pressure eases the strain on your liver.
FDA-approved MASH treatments now include resmetirom (Rezdiffra™) and semaglutide (Wegovy®) alongside diet and exercise.
Because MASH can change over time, doctors track the liver and adjust care and may refer you to a liver specialist.
Your care team decides what’s right for you. This page is educational and not medical advice.
Discover how LIVERFASt™ can help you clearly understand your liver health and give you the insights needed to protect it.
